Nitroglycerin-induced preconditioning: interaction with nitrate tolerance
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چکیده
منابع مشابه
Nitroglycerin-induced preconditioning: interaction with nitrate tolerance.
PRECONDITIONING IS CHARACTERIZED by a remarkable ability to adapt to ischemic stress in a variety of organs (or tissues) with the highest clinical impact in the heart and brain (10, 24). Preconditioning can be induced by several interventions such as ischemia (blockade of blood supply), rapid pacing (increased oxygen demand), or administration of pharmacological agents (pharmacological precondi...
متن کاملNitroglycerin and Nitrate Tolerance
Background. The present study was designed to investigate the intracellular production of cyclic GMP (cGMP) in platelets in response to nitroglycerin and to determine the potential clinical value of platelet cGMP as an indicator of the effects of nitroglycerin and nitrate tolerance. Methods and Results. Platelet cGMP levels and the diameters of the coronary arteries before and 2 minutes after i...
متن کاملNitroglycerin induces late preconditioning against myocardial infarction in conscious rabbits despite development of nitrate tolerance.
BACKGROUND Recent studies suggest that the late phase of ischemic preconditioning (PC) can be mimicked by pretreatment with NO donors. The ability of clinically relevant NO donors to induce PC against infarction, however, has not been evaluated. Furthermore, it is unknown whether tolerance to the hemodynamic actions of nitrates also extends to their PC effects. METHODS AND RESULTS Conscious r...
متن کاملTolerance to nitroglycerin-induced preconditioning of the endothelium: a human in vivo study.
Damage and dysfunction of the vascular endothelium critically influence clinical outcomes after ischemia and reperfusion (I/R). Brief exposure to organic nitrates can protect the vascular endothelium from I/R injury via a mechanism that is similar to ischemic preconditioning and is independent of hemodynamic changes. The clinical relevance of these protective effects clearly depends on whether ...
متن کاملCoadministration of atorvastatin prevents nitroglycerin-induced endothelial dysfunction and nitrate tolerance in healthy humans.
OBJECTIVES We aimed to assess whether concurrent administration of atorvastatin would modify the development of tolerance and endothelial dysfunction associated with sustained nitroglycerin (GTN) therapy in humans. BACKGROUND Animal studies have demonstrated that administration of 3-hydroxy-3 methylglutaryl coenzyme A reductase inhibitors can protect against GTN-induced endothelial dysfunctio...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2010
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.01079.2009